Adenosine Pharmacological Effects:
The effects of Adenosine are quite diverse. They include:
1) A calming effect on the body, which is due to its action on the sympathetic nervous system.
2) An anti-inflammatory effect, which may contribute to the relief of pain.
3) A stimulant effect, which may contribute to the increase in energy levels.
4) A vasodilator effect, which contributes to increased blood flow and oxygenation.
5) An antiplatelet effect, which may contribute to the prevention of blood clots.
6) A diuretic effect, which contributes to the increased production and excretion of urine.
7) A hypotensive effect, which contributes to the increase in blood pressure.
8) An anticoagulant effect, which contributes to an increase in the coagulation of blood.
9) A chronotropic effect, which may contribute to the prolongation of the cardiac cycle.
It is likely that additional effects exist, but these are the most common ones.
- Pharmacological and therapeutic effects of A3 adenosine receptor agonists (P Fishman, S Bar-Yehuda, BT Liang, KA Jacobson – Drug discovery today, 2012 – Elsevier)
- The in vitro pharmacology of ZM 241385, a potent, non‐xanthine, A2a selective adenosine receptor antagonist (SM Poucher, JR Keddie, P Singh… – … of pharmacology, 1995 – Wiley Online Library)
- Effects of xanthine derivatives on lipolysis and on adenosine 3′, 5′-monophosphate phosphodiesterase activity (JA Beavo, NL Rogers, OB Crofford, JG Hardman… – … pharmacology, 1970 – ASPET)
- Protective effect of adenosine and nicotinamide against audiogenic seizure (M Maitre, L Ciesielski, A Lehmann, E Kempf… – … pharmacology, 1974 – Elsevier)
- Effects of adenosine on levels of adenosine cyclic 3′, 5′-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation (RJ HASLAM, GM ROSSON – Molecular Pharmacology, 1975 – ASPET)
- The effect of epinephrine on adenosine 3′, 5′-phosphate levels in the isolated perfused rat heart (GA Robison, RW Butcher, I Øye, HE Morgan… – … Pharmacology, 1965 – ASPET)