What is the Hepatic Microsomal Enzyme System?
The liver contains two major groups of cells: hepatocytes (which make up most of the cell mass) and cholangiocytes (which produce bile). These are called the hepatocellular and cholangiocytic cells respectively. Both types of cells have their own DNA, RNA, proteins, lipids, carbohydrates and vitamins. Cholesterol is one of these substances produced by both types of cells. Liver cells do not contain any blood vessels or lymph nodes. They use their own specialized transport systems to move substances from the bloodstream into the liver where they are used for energy production, or excreted. Some of this waste products are toxic and must be eliminated through urine and feces. Other wastes are essential nutrients which must be stored in special compartments within the body such as fat tissue, muscle tissue, bone marrow, spleen and other organs. When liver cells are damaged, the resulting damage may cause some of these waste products to accumulate in the liver. This accumulation results in a buildup of toxic chemicals that can lead to symptoms like fatigue, loss of appetite, nausea and vomiting. The accumulation of toxins causes the liver to become less efficient at its job and eventually it will fail completely. This condition is known as cirrhosis or failure of the liver.
The human liver is a vital organ that performs hundreds of different functions necessary for life. The liver has a very large amount of blood vessels in it, because it plays a key role in several important parts of the digestive system. These include processing nutrients from food, storing some vital nutrients and removing toxic substances from the blood. It also produces bile, which is stored in the gallbladder before being passed into the small intestine to help digest food and prevent the digestion of waste products.
- Microsomal mixed-function oxidase activity and senescence—I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats … (MB Baird, RJ Nicolosi, HR Massie, HV Samis – Experimental gerontology, 1975 – Elsevier)
- Effect of protein deprivation of male weanling rats on the kinetics of hepatic microsomal enzyme activity (MUK Mgbodile, TC Campbell – The Journal of Nutrition, 1972 – academic.oup.com)
- Induction of drug metabolizing enzyme system in the liver (H Remmer – European Journal of Clinical Pharmacology, 1972 – Springer)
- Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system—I: Effect on substrate interaction with cytochrome P-450 (JR Hayes, MUK Mgbodile, TC Campbell – Biochemical pharmacology, 1973 – Elsevier)
- Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates (C IOANNIDES, DV PARKE – Journal of Pharmacy and …, 1975 – Wiley Online Library)
- The effect of muscular exercise on the microsomal enzyme system of the rat liver (R Frenkl, S Szeberényi – European journal of applied physiology and …, 1980 – Springer)
- Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats (FK Kinoshita, JP Frawley, KP DuBois – Toxicology and applied …, 1966 – Elsevier)